Sunday, March 31, 2013

Pope makes Easter plea for Mideast peace

VATICAN CITY (AP) ? Pope Francis delivered a plea for peace in his first Easter Sunday message to the world, decrying the seemingly endless conflicts in the Middle East and on the Korean peninsula after celebrating Mass at an outdoor altar before more than 250,000 people in flower-bedecked St. Peter's Square.

Francis shared in his flock's exuberance as they celebrated Christianity's core belief that Jesus Christ rose from the dead following crucifixion. After Mass, he stepped aboard an open-topped white popemobile for a cheerful spin through the joyous crowd, kissing babies and patting children on the head.

One admirer of both the pope and of the pope's favorite soccer team, Argentina's Saints of San Lorenzo, insisted that Francis take a team jersey he was waving at the pontiff. A delighted Francis obliged, briefly holding up the shirt, and the crowd roared in approval.

Francis has repeatedly put concern for the poor and suffering at the center of his messages, and he pursued his promotion of the causes of peace and social justice in the Easter speech he delivered from the central balcony of St. Peter's Basilica, the same vantage point above the square where he was introduced to the world as the first Latin American pope on March 13.

The Roman Catholic leader aimed his Easter greetings at "every house and every family, especially where the suffering is greatest, in hospitals, in prisons." Francis prayed that Jesus would inspire people to "change hatred into love, vengeance into forgiveness, war into peace."

As popes before him have, he urged Israelis and Palestinians to resume peace talks and end a conflict that "has lasted all too long." And, in reflecting on the two-year-old Syrian crisis, Francis asked, "How much suffering must there still be before a political solution" can be found?

The pope also expressed desire for a "spirit of reconciliation" on the Korean peninsula, where North Korea says it has entered "a state of war" with South Korea. He also decried warfare and terrorism in Africa, as well as what he called the 21st century's most extensive form of slavery: human trafficking.

The first pontiff to come from the Jesuits, an order with special concern for the poor, and the first pope to name himself after St. Francis, a medieval figure who renounced wealth to preach to the down-and-out, Francis lamented that the world is "still divided by greed looking for easy gain.

Earlier, wearing cream-colored vestments, Francis celebrated Mass on the esplanade in front of the basilica at an altar set up under a white canopy. He frequently bowed his head as if in silent reflection.

The sun competed with clouds in the sky Sunday, but the square was a riot of floral color in Rome, where chilly winter has postponed the blossoming of many flowers. Yellow forsythia and white lilies shone, along with bursts of lavender and pink, from potted azalea, rhododendron, wisteria and other plants.

Francis thanked florists from the Netherlands for donating the flowers. He also advised people to let love transform their lives, or as he put it, "let those desert places in our hearts bloom."

The Vatican had prepared a list of brief, Easter greetings in 65 languages, but Francis didn't read them. The Vatican didn't say why not, but has said that the new pope, at least for now, feels at ease using Italian, the everyday language of the Holy See. Francis also has stressed his role as a pastor to his flock, and, as Bishop of Rome, Italian would be his language.

The pontiff improvised his parting words to the crowd. He repeated his Easter greeting to those "who have come from all over the world to this square at the heart of Christianity" as well as to those "linked by modern technology," a reference to TV and radio coverage as well as social media.

Francis added that he was especially remembering "the weakest and the neediest" and praying that all of humanity be guided along "the paths of justice, love and peace."

In another departure from Easter tradition, Francis won't be heading for some post-holiday relaxation at the Vatican's summer palace in Castel Gandolfo, in the hills southeast of Rome. That retreat is already occupied by his predecessor, Benedict XVI, who went there in the last hours of his papacy on Feb. 28. Benedict became the first pope in 600 years to resign from the position, and eventually is to move back to the Vatican, after a convent there is readied for him.

Francis so far has declined to move into Benedict's former apartment in the Apostolic Palace, into the rooms whose studio overlooks St. Peter's Square. He is still in the Vatican hotel where earlier this month he was staying along with other cardinals participating in the secret conclave to choose Benedict's successor.

While Francis has just begun to make his mark on the church, it is plain he has little desire to embrace much of the pomp customarily associated with the office.

Source: http://news.yahoo.com/pope-makes-easter-pleas-mideast-peace-101523086.html

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Could Ireland's press regulation system work in Britain?

Ireland's press regulations, which include an ombudsman and a council of publishers, public citizens, and journalists, are less restrictive than the proposed British version.

By Jason Walsh,?Correspondent / March 27, 2013

A man collects a copy of a newspaper at a newsstand in London, Oct. 2010. Could Ireland's model of an official Press Council and ombudsman work in Britain?

Ian West/AP/File

Enlarge

With the British government moving ahead on a new media regulator and the UK press in revolt against, some in the country wonder if their neighbors to the west could offer a solution. Could Ireland's model of an official Press Council and ombudsman work in Britain?

Skip to next paragraph Jason Walsh

Ireland Correspondent

Jason Walsh has been the Monitor's Ireland correspondent since 2009, dividing his time primarily between Belfast, Northern Ireland and?Dublin in the Republic of Ireland. During that time he has reported on stumbling blocks in the peace process, the dissident republican threat,?pro-British unionist riots, demands for abortion legislation and Ireland's economic crash.

Recent posts

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Set up by the newspaper industry in response to a government threat to introduce privacy legislation, the 13-member Press Council includes representatives of publishers, members of the public (the appointments are publicly advertised), and one from the National Union of Journalists (NUJ), the leading journalists' union in Britain and Ireland.

Publications that are members, including all of the national newspapers, agree to be bound by its code of conduct, and to recognize the decisions of the council and ombudsman. Membership in the council is not mandatory, but publications that are members are generally subject to lesser damages in the event of successful court actions against them, as a result of the council and ombudsman being "recognized in statute."

The ombudsman, currently?John Horgan, a former Labor party politician and journalism professor, adjudicates on complaints from subjects of newspaper stories, and if agreement cannot be found between all parties involved, he can make a ruling or refer the complaint to the Press Council for a final decision.

Seamus Dooley, the Irish secretary of the NUJ, says regulation has not been proscriptive.

The Press Council's code of conduct is more carrot than stick, and starts with a full-throated defense of a free press, saying: "The freedom to publish is vital to the right of the people to be informed. This freedom includes the right of a newspaper to publish what it?considers to be news, without fear or favour, and the right to comment upon it."

It goes on, however, to detail what the Press Council sees as the correct way for publications to operate, although the tone is more aspirational than condemnatory. For example, retractions must be printed in a prominent place and ordinary members of the public are entitled to privacy.

"We're quite happy with the way it's going," says retired business journalist Martin Fitzpatrick, NUJ's appointee to the Irish Press Council. "We've never had a hugely contentious press. There is a degree of timidity, and you could fault them for not foreseeing the onset of the financial crisis, but that's not down to regulation."

The high opinion of press regulation is not universally held, however, even in the NUJ's Irish ranks.

"[British] newspapers did horrible things, but they also uncovered horrible things that were done. The effect of regulation will not be the protection of people who, through no fault of their own, find themselves at the center of press attention, it will be the protection of the rich and powerful," says Gerard Cunningham, chairman of the NUJ's freelance branch in Ireland.

(Could Ireland's regulation work in Britain? British papers rebel as UK press regulation moves closer to reality)

Mr. Cunningham, who formerly worked in the US, says the culture of the British press is, for demonstrable reasons, comparable to other countries only in very general terms.

"This is about all about competition," he says. "Maybe The New York Times and, to a lesser extent, The Christian Science Monitor have a national reach, but they're not really competing against a regional metro daily," he says.

This situation with each US metro market having a dominant player is in stark contrast with Britain, where 11 national dailies, a clutch of regional newspapers, a few specialist titles, and an independent national Scottish press all slug it out for the same pound.

"The British market is intensely competitive and they try to break every story. They really do publish and be damned," says Cunningham.

In contrast, a staggering 19 daily papers are available on the newsstands nationwide in Ireland, though nine of these are rarely read imports from the US and UK and three more are regional titles from Northern Ireland. Of the seven popular national newspapers in Ireland, two tabloids are "Celtified" editions of British newspapers and two more are hybrids of British and Irish material. All four are members of the Press Council, though their British equivalents object to press regulation.

Having a regulated press hasn't stopped the Irish government from indicating it may seek further powers, though. In February 2012, the publication by the Irish Daily Star of candid photographs of Britain's Duchess of Cambridge, Kate Middleton, prompted Irish Justice Minister Alan Shatter to consider enacting new, stricter privacy legislation. The government has yet to do so, however.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/S0EsSX0n0Ww/Could-Ireland-s-press-regulation-system-work-in-Britain

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Saturday, March 30, 2013

Mozilla to bring console-quality 3D games to Firefox browser ...

2013-game-developers-conference-coverage

3D gaming on a browser? Count us in. At this year?s?Game Developers Conference, Mozilla revealed that it?s working on a technology that could have us playing high-end, console-quality games on the?Firefox browser?without the need for any plugins and installations. Making this possible is?OdinMonkey ? an optimized version of JavaScript currently found on Firefox Nightly that are browser builds for testing purposes.?

A blog post from Mozilla announcing the project describes the highly optimized JavaScript as something that ?supercharges a developer?s gaming code in the browser to enable visually compelling, fast, 3D gaming experiences on the Web.? The project is being developed along with game developer Epic, so it?s no surprise that Mozilla ported Epic?s Unreal Engine on Firefox to demo a game called Citadel?(shown in the video below). It took Epic a total of four days to tweak the gaming engine to work on Firefox. The demo will be available for download online, but the company didn?t mention whether it will commercially release the Unreal Engine for Firefox browsers in the future.?

Mozilla hasn?t only been building this for its desktop version of Firefox, it?s also planning to bring the technology over to the browser?s mobile version for iOS, Android, and of course, Firefox OS. That means you may soon be able to play Web-based 3D games ? along with your arsenal of app games ? on your phones and tablets. Good luck getting any work done!

In addition to Epic Games, Mozilla has also been working with EA, Disney, and?ZeptoLab to port games to Firefox browsers.?The features are expected to roll out bundled with a stable build sometime in June, so we?ll probably hear more about what games will be available from the get-go as the launch date approaches.?

Source: http://www.digitaltrends.com/computing/mozilla-to-bring-3d-browser-games-to-firefox/

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North Gulch property attracts 'activity' | nashvillepost.com

To date, the North Gulch has seen very limited activity, with Eleven North being the only significant development within the modestly emerging urban pocket.

Given Northwestern Mutual Real Estate Services officials have not announced a start date for their 30-plus-acre site located north of Charlotte Avenue and, notwithstanding the rehabbing of the building now home to Anthem and the aforementioned Eleven North, the North Gulch continues to be a mixed-use district essentially in name only.

However, the recent demolition of two small buildings that fronted George L. Davis Boulevard and overlooked Interstate 40/65 may have helped place renewed focus on the area.

Nashville-based Professional Real Estate Developers owns six parcels comprising about 1.85 acres, with the Church Street building most recently home to Performance Studios as the last remaining structure on the site. The owners are asking $4 million for the land and the building.

Larry Beadle, a broker with the Nashville office of Colliers International and the man marketing the site, said the land has been for sale since last summer. The site (seen below in an image courtesy of Google Maps) is noteworthy, he said, because it is not common for almost two acres of downtown property with easy interstate access and located essentially between Midtown and the central business district to be assembled and placed on the market.

?It?s a prime location that would be very difficult to assemble today [in the general Gulch area],? Beadle said.

When asked if the demolition has resulted in increased interest from prospective buyers, Beadle simply said, ?There is activity on the site.?

Beadle said Professional Real Estate Developers wants to sell the property and invest in another site. He declined to disclose the other property.
?

Source: http://nashvillepost.com/blogs/postbusiness/2013/3/29/north_gulch_property_attracts_activity

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Friday, March 29, 2013

OUYA Game Console Enclosure by MakerBot - Thingiverse

All parts were designed and tested using MakerBot PLA Filament, but may print successfully using ABS.

Case, Lid, & Spring
Infill: 10%
Shells: 1 shell (total; so 0 extra shells)
Layer height resolution: 0.20-0.25 mm

Button (use a translucent color)
Infill: 0%
Shells: 50 (fifty!)
Layer height resolution: 0.3 mm. Turn the active cooling fan ON.

Instructions:
Slot the Button into the spring from the smooth side (the side that printed against the build plate), then give the button a quarter turn to lock it in place.

Slot the long spring arm into the lid (it will only fit one way) and gently work the other two spring arms into their slots. Make sure you don't bend the spring too far in any direction. Make sure the button can move freely and isn't catching anywhere.

Slot the OUYA hardware into the printed case.

Align the two forked guides on the inside of the lid with the OUYA board and press the lid onto the case. It should seat with a satisfying snap.

Source: http://www.thingiverse.com/thing%3A66411

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Wednesday, March 27, 2013

Researchers discover primary role of the olivocochlear efferent system

Researchers discover primary role of the olivocochlear efferent system [ Back to EurekAlert! ] Public release date: 27-Mar-2013
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Contact: Mary Leach
Mary_Leach@meei.harvard.edu
Massachusetts Eye and Ear Infirmary

Light shed on the natural mechanism that protects ears from hearing loss

New research from the Massachusetts Eye and Ear, Harvard Medical School and Harvard Program in Speech and Hearing Bioscience and Technology may have discovered a key piece in the puzzle of how hearing works by identifying the role of the olivocochlear efferent system in protecting ears from hearing loss. The findings could eventually lead to screening tests to determine who is most susceptible to hearing loss. Their paper is published today in the Journal of Neuroscience.

Until recently, it was common knowledge that exposure to a noisy environment (concert, iPod, mechanical tools, firearm, etc.), could lead to permanent or temporary hearing loss. Most audiologists would assess the damage caused by this type of exposure by measuring hearing thresholds, the lowest level at which one starts to detect/sense a sound at a particular frequency (pitch). Drs. Sharon Kujawa and Charles Liberman, both researchers at Mass. Eye and Ear, showed in 2009 that noise exposures leading to a temporary hearing loss in mice (when hearing thresholds return to what they were before exposure) in fact can be associated with cochlear neuropathy, a situation in which, despite having a normal threshold, a portion of auditory nerve fibers is missing).

The inner ear, the organ that converts sounds into messages that will be conveyed to and decoded by the brain, receives in turn fibers from the central nervous system. Those fibers are known as the olivocochlear efferent system. Up to now, the involvement of this efferent system in the protection from acoustic injury although clearly demonstrated has been a matter of debate because all the previous experiments were probing its protective effects following noise exposures very unlikely to be found in nature.

Stephane Maison, Ph.D., investigator at the Eaton-Peabody Laboratory at Mass. Eye and Ear and lead author, explains. "Humans are currently exposed to the type of noise used in those experiments but it's hard to conceive that some vertebrates, thousands of years ago, were submitted to stimuli similar to those delivered by speakers. So many researchers believed that the protective effects of the efferent system were an epiphenomenon not its true function."

Instead of using loud noise exposures evoking a change in hearing threshold, we used a moderate noise exposure at a level similar to those found in restaurants, conferences, malls, and also in nature (some frogs emit vocalizations at similar or higher levels) and instead of looking at thresholds, we looked for signs of cochlear neuropathy, Dr. Maison continued.

The researchers demonstrated that such moderate exposure lead to cochlear neuropathy (loss of auditory nerve fibers), which causes difficulty to hear in noisy environments.

"This is tremendously important because all of us are submitted to such acoustic environments and it takes a lot of auditory nerve fiber loss before it gets to be detected by simply measuring thresholds as it's done when preforming an audiogram," Dr. Maison said. "The second important discovery is that, in mice where the efferent system has been surgically removed, cochlear neuropathy is tremendously exacerbated. That second piece proves that the efferent system does play a very important role in protecting the ear from cochlear neuropathy and we may have found its main function."

The researchers say they are excited about this discovery because the strength of the efferent system can be recorded non-invasively in humans and a non-invasive assay to record the efferent system strength has already been developed and shows that one is able to predict vulnerability to acoustic injury (Maison and Liberman, Predicting vulnerability to acoustic injury with a noninvasive assay of olivocochlear reflex strength, Journal of Neuroscience, 20:4701-4707, 2000).

"One could envision applying this assay or a modified version of it to human populations to screen for individuals most at risk in noise environments," Dr. Maison concluded.

###

This work was supported by the National Institute on Deafness and Other Communication disorders (Grants RO1 DC 0188 and P30 DC 05209).

A full list of authors and affiliations and full acknowledgement of all contributors is available in the pdf of the paper, "Efferent Feedback Minimizes Cochlear Neuropathy from Moderate Noise Exposure."

About Massachusetts Eye and Ear

Mass. Eye and Ear clinicians and scientists are driven by a mission to find cures for blindness, deafness and diseases of the head and neck. After uniting with Schepens Eye Research Institute in 2011, Mass. Eye and Ear in Boston became the world's largest vision and hearing research center, offering hope and healing to patients everywhere through discovery and innovation. Mass. Eye and Ear is home to the Eaton-Peabody Laboratories, the largest collection of basic hearing laboratories. Mass. Eye and Ear is a Harvard Medical School teaching hospital and trains future medical leaders in ophthalmology and otolaryngology, through residency as well as clinical and research fellowships. Internationally acclaimed since its founding in 1824, Mass. Eye and Ear employs full-time, board-certified physicians who offer high-quality and affordable specialty care that ranges from the routine to the very complex. U.S. News & World Report's "Best Hospitals Survey" has consistently ranked the Mass. Eye and Ear Departments of Otolaryngology and Ophthalmology as top five in the nation.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Researchers discover primary role of the olivocochlear efferent system [ Back to EurekAlert! ] Public release date: 27-Mar-2013
[ | E-mail | Share Share ]

Contact: Mary Leach
Mary_Leach@meei.harvard.edu
Massachusetts Eye and Ear Infirmary

Light shed on the natural mechanism that protects ears from hearing loss

New research from the Massachusetts Eye and Ear, Harvard Medical School and Harvard Program in Speech and Hearing Bioscience and Technology may have discovered a key piece in the puzzle of how hearing works by identifying the role of the olivocochlear efferent system in protecting ears from hearing loss. The findings could eventually lead to screening tests to determine who is most susceptible to hearing loss. Their paper is published today in the Journal of Neuroscience.

Until recently, it was common knowledge that exposure to a noisy environment (concert, iPod, mechanical tools, firearm, etc.), could lead to permanent or temporary hearing loss. Most audiologists would assess the damage caused by this type of exposure by measuring hearing thresholds, the lowest level at which one starts to detect/sense a sound at a particular frequency (pitch). Drs. Sharon Kujawa and Charles Liberman, both researchers at Mass. Eye and Ear, showed in 2009 that noise exposures leading to a temporary hearing loss in mice (when hearing thresholds return to what they were before exposure) in fact can be associated with cochlear neuropathy, a situation in which, despite having a normal threshold, a portion of auditory nerve fibers is missing).

The inner ear, the organ that converts sounds into messages that will be conveyed to and decoded by the brain, receives in turn fibers from the central nervous system. Those fibers are known as the olivocochlear efferent system. Up to now, the involvement of this efferent system in the protection from acoustic injury although clearly demonstrated has been a matter of debate because all the previous experiments were probing its protective effects following noise exposures very unlikely to be found in nature.

Stephane Maison, Ph.D., investigator at the Eaton-Peabody Laboratory at Mass. Eye and Ear and lead author, explains. "Humans are currently exposed to the type of noise used in those experiments but it's hard to conceive that some vertebrates, thousands of years ago, were submitted to stimuli similar to those delivered by speakers. So many researchers believed that the protective effects of the efferent system were an epiphenomenon not its true function."

Instead of using loud noise exposures evoking a change in hearing threshold, we used a moderate noise exposure at a level similar to those found in restaurants, conferences, malls, and also in nature (some frogs emit vocalizations at similar or higher levels) and instead of looking at thresholds, we looked for signs of cochlear neuropathy, Dr. Maison continued.

The researchers demonstrated that such moderate exposure lead to cochlear neuropathy (loss of auditory nerve fibers), which causes difficulty to hear in noisy environments.

"This is tremendously important because all of us are submitted to such acoustic environments and it takes a lot of auditory nerve fiber loss before it gets to be detected by simply measuring thresholds as it's done when preforming an audiogram," Dr. Maison said. "The second important discovery is that, in mice where the efferent system has been surgically removed, cochlear neuropathy is tremendously exacerbated. That second piece proves that the efferent system does play a very important role in protecting the ear from cochlear neuropathy and we may have found its main function."

The researchers say they are excited about this discovery because the strength of the efferent system can be recorded non-invasively in humans and a non-invasive assay to record the efferent system strength has already been developed and shows that one is able to predict vulnerability to acoustic injury (Maison and Liberman, Predicting vulnerability to acoustic injury with a noninvasive assay of olivocochlear reflex strength, Journal of Neuroscience, 20:4701-4707, 2000).

"One could envision applying this assay or a modified version of it to human populations to screen for individuals most at risk in noise environments," Dr. Maison concluded.

###

This work was supported by the National Institute on Deafness and Other Communication disorders (Grants RO1 DC 0188 and P30 DC 05209).

A full list of authors and affiliations and full acknowledgement of all contributors is available in the pdf of the paper, "Efferent Feedback Minimizes Cochlear Neuropathy from Moderate Noise Exposure."

About Massachusetts Eye and Ear

Mass. Eye and Ear clinicians and scientists are driven by a mission to find cures for blindness, deafness and diseases of the head and neck. After uniting with Schepens Eye Research Institute in 2011, Mass. Eye and Ear in Boston became the world's largest vision and hearing research center, offering hope and healing to patients everywhere through discovery and innovation. Mass. Eye and Ear is home to the Eaton-Peabody Laboratories, the largest collection of basic hearing laboratories. Mass. Eye and Ear is a Harvard Medical School teaching hospital and trains future medical leaders in ophthalmology and otolaryngology, through residency as well as clinical and research fellowships. Internationally acclaimed since its founding in 1824, Mass. Eye and Ear employs full-time, board-certified physicians who offer high-quality and affordable specialty care that ranges from the routine to the very complex. U.S. News & World Report's "Best Hospitals Survey" has consistently ranked the Mass. Eye and Ear Departments of Otolaryngology and Ophthalmology as top five in the nation.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/meae-rdp032713.php

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Gilman elected inaugural Fellow of the American Association for Cancer Research

Gilman elected inaugural Fellow of the American Association for Cancer Research [ Back to EurekAlert! ] Public release date: 26-Mar-2013
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Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

DALLAS March 26, 2013 Nobel Laureate Dr. Alfred Gilman, Regental Professor Emeritus of Pharmacology at UT Southwestern Medical Center, has been elected one of the inaugural Fellows of the American Association for Cancer Research, the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer.

Dr. Gilman's work identifying G proteins and their critical role in how cells communicate to function properly has been instrumental to understanding numerous diseases, including the development of tumors. Its recognized significance resulted in Dr. Gilman sharing the 1994 Nobel Prize in Physiology or Medicine.

"It is an honor to be recognized with such a distinguished assembly of scientists and physicians," Dr. Gilman said of the AACR Fellowship. "Hopefully, the creation of the academy will bring additional needed attention to the importance of cancer research, and ongoing efforts to prevent and treat the many forms of this disease."

The AACR Academy was created to recognize and honor distinguished researchers whose major scientific contributions have propelled significant innovation and progress against cancer.

"Our Board of Directors made the decision to establish the AACR Academy as a mechanism for recognizing scientists whose contributions to the cancer field have had an extraordinary impact. Membership in the Fellows of the AACR Academy will be the most prestigious honor bestowed by the American Association for Cancer Research," said Dr. Margaret Foti, Chief Executive Officer of the AACR.

Founded in 1907, the AACR includes more than 34,000 laboratory, translational, and clinical researchers; population scientists; other health care professionals; and cancer advocates from more than 90 countries. The AACR also publishes eight peer-reviewed scientific journals and a magazine for cancer survivors, patients, and their caregivers; funds meritorious research; and is the scientific partner of Stand Up To Cancer.

"Dr. Gilman's enduring discovery of G proteins and the critical functions continue to fuel important research in the field of cancer and have provided the basis for therapeutic advancement," said Dr. Daniel K. Podolsky, President of UT Southwestern. "His contributions as a scientist, teacher, and leader are legion, and his dedication to serving the scientific community and UT Southwestern is an ongoing source of pride."

Dr. Gilman recently served as Chief Scientific Officer of the Cancer Prevention and Research Institute of Texas and previously served UT Southwestern as Dean of UT Southwestern Medical School, Executive Vice President for Academic Affairs and Provost for the Medical Center, and as Director of the Cecil H. and Ida Green Comprehensive Center for Molecular, Computational and Systems Biology. Dr. Gilman served 24 years as Chairman of Pharmacology, and was also the primary editor of the best known textbook of Pharmacology, Goodman and Gilman's The Pharmacological Basis of Therapeutics.

Dr. Gilman was awarded the 1994 Nobel Prize jointly with Dr. Martin Rodbell of the National Institute of Environmental Health Sciences for their discovery of G proteins, which are critical to the proper function of a cell.

Trillions of cells interact in concert with each other in humans. The cells communicate with each other using chemical signals, and the information inherent in these signals needs to gain access to the cell interior. G proteins are crucial middle men in interpreting, transmitting, and amplifying these regulatory signals as they move from the outside to the inside of the cell.

Disruptions to the cellular communication process are the foundation for many diseases. For example, overactive G proteins are a characteristic of some tumors, while other interruptions to the process can lead to skeletal deformation, metabolic problems, and compromised immunity.

###

About UT Southwestern Medical Center

UT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institution's faculty has many distinguished members, including five who have been awarded Nobel Prizes since 1985.Numbering more than 2,700, the faculty is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide medical care in 40 specialties to nearly 100,000 hospitalized patients and oversee more than 2.1 million outpatient visits a year.

This news release is available on our World Wide Web home page at http://www.utsouthwestern.edu/home/news/index.html

To automatically receive news releases from UT Southwestern via email, subscribe at http://www.utsouthwestern.edu/receivenews


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?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Gilman elected inaugural Fellow of the American Association for Cancer Research [ Back to EurekAlert! ] Public release date: 26-Mar-2013
[ | E-mail | Share Share ]

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

DALLAS March 26, 2013 Nobel Laureate Dr. Alfred Gilman, Regental Professor Emeritus of Pharmacology at UT Southwestern Medical Center, has been elected one of the inaugural Fellows of the American Association for Cancer Research, the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer.

Dr. Gilman's work identifying G proteins and their critical role in how cells communicate to function properly has been instrumental to understanding numerous diseases, including the development of tumors. Its recognized significance resulted in Dr. Gilman sharing the 1994 Nobel Prize in Physiology or Medicine.

"It is an honor to be recognized with such a distinguished assembly of scientists and physicians," Dr. Gilman said of the AACR Fellowship. "Hopefully, the creation of the academy will bring additional needed attention to the importance of cancer research, and ongoing efforts to prevent and treat the many forms of this disease."

The AACR Academy was created to recognize and honor distinguished researchers whose major scientific contributions have propelled significant innovation and progress against cancer.

"Our Board of Directors made the decision to establish the AACR Academy as a mechanism for recognizing scientists whose contributions to the cancer field have had an extraordinary impact. Membership in the Fellows of the AACR Academy will be the most prestigious honor bestowed by the American Association for Cancer Research," said Dr. Margaret Foti, Chief Executive Officer of the AACR.

Founded in 1907, the AACR includes more than 34,000 laboratory, translational, and clinical researchers; population scientists; other health care professionals; and cancer advocates from more than 90 countries. The AACR also publishes eight peer-reviewed scientific journals and a magazine for cancer survivors, patients, and their caregivers; funds meritorious research; and is the scientific partner of Stand Up To Cancer.

"Dr. Gilman's enduring discovery of G proteins and the critical functions continue to fuel important research in the field of cancer and have provided the basis for therapeutic advancement," said Dr. Daniel K. Podolsky, President of UT Southwestern. "His contributions as a scientist, teacher, and leader are legion, and his dedication to serving the scientific community and UT Southwestern is an ongoing source of pride."

Dr. Gilman recently served as Chief Scientific Officer of the Cancer Prevention and Research Institute of Texas and previously served UT Southwestern as Dean of UT Southwestern Medical School, Executive Vice President for Academic Affairs and Provost for the Medical Center, and as Director of the Cecil H. and Ida Green Comprehensive Center for Molecular, Computational and Systems Biology. Dr. Gilman served 24 years as Chairman of Pharmacology, and was also the primary editor of the best known textbook of Pharmacology, Goodman and Gilman's The Pharmacological Basis of Therapeutics.

Dr. Gilman was awarded the 1994 Nobel Prize jointly with Dr. Martin Rodbell of the National Institute of Environmental Health Sciences for their discovery of G proteins, which are critical to the proper function of a cell.

Trillions of cells interact in concert with each other in humans. The cells communicate with each other using chemical signals, and the information inherent in these signals needs to gain access to the cell interior. G proteins are crucial middle men in interpreting, transmitting, and amplifying these regulatory signals as they move from the outside to the inside of the cell.

Disruptions to the cellular communication process are the foundation for many diseases. For example, overactive G proteins are a characteristic of some tumors, while other interruptions to the process can lead to skeletal deformation, metabolic problems, and compromised immunity.

###

About UT Southwestern Medical Center

UT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institution's faculty has many distinguished members, including five who have been awarded Nobel Prizes since 1985.Numbering more than 2,700, the faculty is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide medical care in 40 specialties to nearly 100,000 hospitalized patients and oversee more than 2.1 million outpatient visits a year.

This news release is available on our World Wide Web home page at http://www.utsouthwestern.edu/home/news/index.html

To automatically receive news releases from UT Southwestern via email, subscribe at http://www.utsouthwestern.edu/receivenews


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Source: http://www.eurekalert.org/pub_releases/2013-03/usmc-gei032613.php

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Tuesday, March 26, 2013

Italian court orders retrial of Amanda Knox

ROME (Reuters) - Italy's top court on Tuesday overturned the 2011 acquittal of American student Amanda Knox and her former boyfriend Raffaele Sollecito for the murder of Briton Meredith Kercher, and ordered a retrial.

The decision by the Court of Cassation is a new twist to a long-running case whose initial handling was sharply criticized by independent forensic experts.

Prosecutors accused Knox and Sollecito of killing Kercher in 2007 during a drug-fuelled sexual assault.

The two were initially found guilty and sentenced to 26 and 25 years in prison respectively after a trial that grabbed headlines all over the world.

In 2011, their convictions were overturned after forensic investigators challenged police scientific evidence, saying there had been multiple errors in the investigation. Knox and Sollecito were released after serving four years in prison.

A third person, Ivorian Rudy Guede, was found guilty and sentenced to 16 years in a separate trial. He is now the only person serving time for the murder, although prosecutors say he could not have killed Kercher by himself.

Last year, prosecutors filed a motion to appeal against the acquittals, calling the verdicts "contradictory and illogical".

Italy's top appeal court made the ruling on Tuesday after examining whether there were procedural irregularities which gave grounds for a retrial, rather than assessing the details of the case. Its reasons will be announced later.

The new trial will be held before a court in Florence.

Kercher, a student at Leeds University, was 21 when she died.

Knox returned to her Seattle-area home after she was released from prison in Italy and had been scheduled to speak publicly about the trial for the first time on American television in April, when her book about the case is due to be released.

(Reporting By Virginia Alimenti, writing by Catherine Hornby; editing by Barry Moody)

Source: http://news.yahoo.com/italy-court-orders-amanda-knox-retrial-meredith-kercher-091550180.html

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Chimps, gorillas, other apes struggling to survive

BANGKOK (AP) ? The multibillion-dollar trade in illegal wildlife ? clandestine trafficking that has driven iconic creatures like the tiger to near-extinction ? is also threatening the survival of great apes, a new U.N. report says.

Endangered chimpanzees, orangutans, gorillas and bonobos are disappearing from the wild in frightening numbers, as private owners pay top dollar for exotic pets, while disreputable zoos, amusement parks and traveling circuses clamor for smuggled primates to entertain audiences.

More than 22,000 great apes are estimated to have been traded illegally over a seven-year period ending in 2011. That's about 3,000 a year; more than half are chimpanzees, the U.N. report said.

"These great apes make up an important part of our natural heritage. But as with all things of value, great apes are used by man for commercial profit and the illegal trafficking of the species constitutes a serious threat to their existence," Henri Djombo, a government minister from the Republic of Congo, was quoted as saying.

The U.N. report paints a dire picture of the fight to protect vulnerable and dwindling flora and fauna from organized criminal networks that often have the upper hand.

Apes are hunted in their own habitats, which are concentrated in central and western Africa, by sophisticated smugglers who transport them on private cargo planes using small airstrips in the African bush. Their destination is usually the Middle East and Asia.

In countries like Saudi Arabia, United Arab Emirates and Lebanon, great apes are purchased to display as show pieces in private gardens and menageries.

In Asia, the animals are typically destined for public zoos and amusement parks. China is a main destination for gorillas and chimpanzees. Thailand and Cambodia have recorded cases of orangutans being used for entertainment in "clumsy boxing matches," the report said.

Lax enforcement and corruption make it easy to smuggle the animals through African cities like Nairobi, Kenya, and Khartoum, Sudan, which are trafficking hubs. Bangkok, the Thai capital, is a major hub for the orangutan trade.

Conditions are usually brutal. In February 2005, customs officials at the Nairobi airport seized a large crate that had arrived from Egypt. The crate held six chimpanzees and four monkeys, stuffed into tiny compartments. The crate had been refused at the airport in Cairo, a well-known trafficking hub for shipment to the Middle East, and returned to Kenya. One chimp died of hunger and thirst.

The proliferation of logging and mining camps throughout Africa has also increased the demand for primate meat. Adults and juveniles are killed for consumption, and their orphans are captured to sell into the live trade. Villagers also pluck primates out of rural areas to sell in the cities.

Humans also have been encroaching upon and destroying the primates' natural habitats, destroying their forest homes to build infrastructure and for other purposes. That forces the animals to move into greater proximity and conflict with people.

Sometimes animals are even the victims of war.

Arrests are rare largely because authorities in Africa, where most great apes originate, do not have the policing resources to cope with the criminal poaching networks. Corruption is rampant and those in authority sometimes are among those dealing in the illegal trade. Between 2005 and 2011, only 27 arrests were made in Africa and Asia.

The Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) regulates the trade of animals and plants to ensure their survival. Under the agreement, trade in great apes caught in the wild is illegal. But traffickers often get around that by falsely declaring animals as bred in captivity.

The orangutan is the only great ape found in Asia. One species, the Sumatran orangutan, is critically endangered, with its population having dropped by 80 percent over the last 75 years. Their numbers are in great peril due to the pace of land clearance and forest destruction for industrial or agricultural use.

The report estimates that nearly all of the orangutan's natural habitat will be disturbed or destroyed by the year 2030.

"There are no wild spaces left for them," said Douglas Cress, a co-author of the report and head of a U.N. sponsored program that works for the survival of great apes. "There'll be nothing left at this rate. It's down to the bone. If it disappears, they go, too."

___

Follow Pamela Sampson on Twitter at http://twitter.com/pamelasampson

Source: http://news.yahoo.com/chimps-gorillas-other-apes-struggling-survive-051137577.html

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Heather Bresette And Two Sons Injured In Birmingham Airport Billboard Accident Improving At Hospital

MONTGOMERY, Ala. -- As airport officials tried to figure out how a 300-pound arrival-departure panel fell off the wall and onto a family, the mother of a boy who was killed by the sign lay in a hospital with her own injuries, still unaware of what happened.

Heather Bresette and two of her other sons were seriously hurt when the panel fell Friday at the Birmingham-Shuttlesworth International Airport. She had surgeries for broken ankles and a crushed pelvis over the weekend, but she was still in intensive care and unconscious.

"She does not know that her baby is dead," the family's priest, the Rev. Don Farnan, said.

The Bresettes, a family of seven, took a weeklong spring break vacation to Destin, Fla., and were about to fly home to Overland Park, Kan., when the flight information panel fell.

Luke Bresette, the middle of five children, was killed. His brother, 5-year-old Tyler, suffered a concussion. His 8-year-old brother, Sam, had a broken leg and nose.

Tyler was released from a children's hospital Sunday; Sam was still there.

The boys' father, Ryan Bresette, and an older son and daughter, were at the airport when the sign fell but not hurt.

Heather Bresette's condition improved to serious on Sunday, University Hospital spokeswoman Nicole Wyatt said.

During their vacation, the family swam in the Gulf of Mexico and Luke went parasailing for the first time.

"His dad said he was thrilled. He was an adventurous kid. He loved sports," said Farnan, a priest at St. Thomas More in Kansas City, Mo.

After the sign fell, it took six people to lift the large board and a dozen people to hold it up while first responders administered aid. Officials were investigating how the sign fell at the newly renovated airport and took down an identical billboard on Saturday.

The renovated concourse opened March 13. It was part of an ongoing $200 million upgrade of Birmingham's airport. The construction began in June 2011 and is being overseen by Brasfield & Gorrie Global Services Group.

The Birmingham-based company said in a statement it was working with airport authorities to determine why the sign fell.

"This is a terrible tragedy that none of us fully understand, and we hope that the family who lost their loved one will find strength through prayer and the support of all of us," the statement said.

At St. Thomas More, hundreds of worshippers showed up for a Saturday morning Mass that usually has about 75 people. Luke's uncle Alex Bresette placed a Rockhurst High School jersey on the altar.

"He would have been in the Class of 2020," he told the Kansas City Star.

Ryan Bresette said in a message on Facebook that words cannot describe the pain the family feels.

In a note to his son, he wrote, "I miss and love Luke so very much. I love you Luke!"

"Ryan is especially grateful for the amazing support of the people in Birmingham. They even started a fund for the family at a bank there," Farnan said. "There are long, loving arms that stretch between Birmingham and Kansas City."

Also on HuffPost:

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Source: http://www.huffingtonpost.com/2013/03/24/heather-bresette-birmingham-airport-billboard_n_2945585.html

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Meteorites reveal the secrets of last month's Russian fireball

Shards of meteorite, remnants of the fireball that streaked across Russia's skies on February 15, are giving scientists clues to the composition and origin of the space rock.

By Leonard David,?Space.com / March 21, 2013

A meteor streaked across the sky of Russia?s Ural Mountains on Friday morning, Feb. 15, causing sharp explosions injuring over 100 people, including many hurt by broken glass. Scientists have recovered broken fragments of the superbolide and are examining them for clues to its origin.

Nasha gazeta, www.ng.kz / AP

Enlarge Photos

Scientists studying small pieces of the meteor that exploded over the Russian city of Chelyabinsk on Feb. 15 are working to glean new insights into the rare impact by a space rock.

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Based on the meteorite analysis, researchers have determined that last month's meteor explosion in Russia ? which scientists call a superbolide ? produced a shock wave that reached the ground. That shock shattered windows and injured some 1,500 people due to flying glass.

The blast also created a shower of stony meteorites that fell to Earth in an impact region more than 60 miles (100 kilometers) long.

Thinly sliced meteorites

Some of the Chelyabinsk meteorite samples have made their way to planetary scientist Larry Taylor, director of the Planetary Geosciences Institute at the University of Tennessee in Knoxville, who obtained the superbolide samples with the help of Russian colleagues.?

"I got three pieces that were completely coated with black fusion crust. The total of them is less than 10 grams," Taylor told SPACE.com here at the 44th Lunar and Planetary Science Conference.

Initially, the meteorite specimens were polished and thinly sliced for a detailed inspection under a petrographic microscope. The device is a type of optical microscope used in petrology and optical mineralogy that scientists are employing to identify rocks and minerals within the thin meteorite slices.

The small samples will undergo further scrutiny over the next few months, Taylor said.

"We've just started to skim the top of it," he added.

Tapping into superbolide secrets

Taylor and his associates are now deciding the best tactics to further reveal what stories the specimens have to tell.

"The magnitude of the explosion led a whole lot of us to believe that it must have been a very volatile-rich meteor that was coming in ? because it exploded so vigorously," Taylor said. Volatile materials are those that evaporate easily. ?In fact, everything we found so far points to an ordinary chondrite."

About 90 percent of stony meteorites are classified as ordinary chondrites, space rocks that are lacking in volatile materials.

"It is ordinary because it's common," Taylor said. "But it is special because it contains such a wide array of things ? a whole menagerie of things all in one."?

Source: http://rss.csmonitor.com/~r/feeds/science/~3/-mNZ-WM7BWo/Meteorites-reveal-the-secrets-of-last-month-s-Russian-fireball

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Study warns on location data privacy

Link Information - Click to View

Study warns on location data privacy
A study of mobile phone data - used by advertisers or even released publicly - reveals that individuals can be identified using only four location points.

Source: BBC News
Posted on: Monday, Mar 25, 2013, 8:48am
Views: 15

Source: http://www.labspaces.net/127430/Study_warns_on_location_data_privacy

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Hiker rescued after days pinned under rocks

By Olsen Ebright, NBCSanDiego.com

RIVERSIDE, Calif. -- Rescue workers saved a hiker who was trapped under rocks for as many as eight days without any food and water, according to firefighters.

Hiker Ramon Llamas and his German shepherd-mix "Mol?" discovered the man about 8:30 a.m. PT (11:30 a.m. ET) Monday on?Mount Rubidoux in Riverside, Calif.

"I said to the guy, 'You need help? Are you OK?' When he reacted, he says, 'Somebody there? Please don't leave me. Don't leave me,'" Llamas said. "'You got some water?' And I gave him water, and a minute later, he said, 'You got some more?' Are you by yourself? 'Yeah, I'm a tourist here. I'm hungry.'"

About an hour later, rescue workers were able to free the 44-year-old man whose foot was pinned under rocks. He was hospitalized with symptoms of dehydration.

More news from NBCSanDiego.com

The man -- who identified himself as Paul -- told firefighters he lived "back east" and was trapped for four to six days, although officials said it could have been as long as eight days because the victim was unconscious at times.

The man did not have any food or water with him, firefighters said.

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/29fe2149/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A30C260C1746730A30Ehiker0Erescued0Eafter0Edays0Epinned0Eunder0Erocks0Dlite/story01.htm

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Developing our sense of smell

Developing our sense of smell [ Back to EurekAlert! ] Public release date: 25-Mar-2013
[ | E-mail | Share Share ]

Contact: Deborah Williams-Hedges
debwms@caltech.edu
626-395-3227
California Institute of Technology

Caltech biologists pinpoint the origin of olfactory nerve cells

PASADENA, Calif.When our noses pick up a scent, whether the aroma of a sweet rose or the sweat of a stranger at the gym, two types of sensory neurons are at work in sensing that odor or pheromone. These sensory neurons are particularly interesting because they are the only neurons in our bodies that regenerate throughout adult lifeas some of our olfactory neurons die, they are soon replaced by newborns. Just where those neurons come from in the first place has long perplexed developmental biologists.

Previous hypotheses about the origin of these olfactory nerve cells have given credit to embryonic cells that develop into skin or the central nervous system, where ear and eye sensory neurons, respectively, are thought to originate. But biologists at the California Institute of Technology (Caltech) have now found that neural-crest stem cellsmultipotent, migratory cells unique to vertebrates that give rise to many structures in the body such as facial bones and smooth musclealso play a key role in building olfactory sensory neurons in the nose.

"Olfactory neurons have long been thought to be solely derived from a thickened portion of the ectoderm; our results directly refute that concept," says Marianne Bronner, the Albert Billings Ruddock Professor of Biology at Caltech and corresponding author of a paper published in the journal eLIFE on March 19 that outlines the findings.

The two main types of sensory neurons in the olfactory system are ciliated neurons, which detect volatile scents, and microvillous neurons, which usually sense pheromones. Both of these types are found in the tissue lining the inside of the nasal cavity and transmit sensory information to the central nervous system for processing.

In the new study, the researchers showed that during embryonic development, neural-crest stem cells differentiate into the microvillous neurons, which had long been assumed to arise from the same source as the odor-sensing ciliated neurons. Moreover, they demonstrated that different factors are necessary for the development of these two types of neurons. By eliminating a gene called Sox10, they were able to show that formation of microvillous neurons is blocked whereas ciliated neurons are unaffected.

They made this discovery by studying the development of the olfactory system in zebrafisha useful model organism for developmental biology studies due to the optical clarity of the free-swimming embryo. Understanding the origins of olfactory neurons and the process of neuron formation is important for developing therapeutic applications for conditions like anosmia, or the inability to smell, says Bronner.

"A key question in developmental biologythe extent of neural-crest stem cell contribution to the olfactory systemhas been addressed in our paper by multiple lines of experimentation," says Ankur Saxena, a postdoctoral scholar in Bronner's laboratory and lead author of the study. "Olfactory neurons are unique in their renewal capacity across species, so by learning how they form, we may gain insights into how neurons in general can be induced to differentiate or regenerate. That knowledge, in turn, may provide new avenues for pursuing treatment of neurological disorders or injury in humans."

Next, the researchers will examine what other genes, in addition to Sox10, play a role in the process by which neural-crest stem cells differentiate into microvillous neurons. They also plan to look at whether or not neural-crest cells give rise to new microvillous neurons during olfactory regeneration that happens after the embryonic stage of development.

###

Funding for the research outlined in the eLIFE paper, "Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish," was provided by the National Institutes of Health and the Gordon Ross Postdoctoral Fellowship. Brian N. Peng, a former undergraduate student (BS '12) at Caltech, also contributed to the study. A new open-access, high-impact journal, eLIFE is backed by three of the most prestigious biomedical research funders in the world: the Howard Hughes Medical Institute, the Max Planck Society, and the Wellcome Trust.

Written by Katie Neith


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Developing our sense of smell [ Back to EurekAlert! ] Public release date: 25-Mar-2013
[ | E-mail | Share Share ]

Contact: Deborah Williams-Hedges
debwms@caltech.edu
626-395-3227
California Institute of Technology

Caltech biologists pinpoint the origin of olfactory nerve cells

PASADENA, Calif.When our noses pick up a scent, whether the aroma of a sweet rose or the sweat of a stranger at the gym, two types of sensory neurons are at work in sensing that odor or pheromone. These sensory neurons are particularly interesting because they are the only neurons in our bodies that regenerate throughout adult lifeas some of our olfactory neurons die, they are soon replaced by newborns. Just where those neurons come from in the first place has long perplexed developmental biologists.

Previous hypotheses about the origin of these olfactory nerve cells have given credit to embryonic cells that develop into skin or the central nervous system, where ear and eye sensory neurons, respectively, are thought to originate. But biologists at the California Institute of Technology (Caltech) have now found that neural-crest stem cellsmultipotent, migratory cells unique to vertebrates that give rise to many structures in the body such as facial bones and smooth musclealso play a key role in building olfactory sensory neurons in the nose.

"Olfactory neurons have long been thought to be solely derived from a thickened portion of the ectoderm; our results directly refute that concept," says Marianne Bronner, the Albert Billings Ruddock Professor of Biology at Caltech and corresponding author of a paper published in the journal eLIFE on March 19 that outlines the findings.

The two main types of sensory neurons in the olfactory system are ciliated neurons, which detect volatile scents, and microvillous neurons, which usually sense pheromones. Both of these types are found in the tissue lining the inside of the nasal cavity and transmit sensory information to the central nervous system for processing.

In the new study, the researchers showed that during embryonic development, neural-crest stem cells differentiate into the microvillous neurons, which had long been assumed to arise from the same source as the odor-sensing ciliated neurons. Moreover, they demonstrated that different factors are necessary for the development of these two types of neurons. By eliminating a gene called Sox10, they were able to show that formation of microvillous neurons is blocked whereas ciliated neurons are unaffected.

They made this discovery by studying the development of the olfactory system in zebrafisha useful model organism for developmental biology studies due to the optical clarity of the free-swimming embryo. Understanding the origins of olfactory neurons and the process of neuron formation is important for developing therapeutic applications for conditions like anosmia, or the inability to smell, says Bronner.

"A key question in developmental biologythe extent of neural-crest stem cell contribution to the olfactory systemhas been addressed in our paper by multiple lines of experimentation," says Ankur Saxena, a postdoctoral scholar in Bronner's laboratory and lead author of the study. "Olfactory neurons are unique in their renewal capacity across species, so by learning how they form, we may gain insights into how neurons in general can be induced to differentiate or regenerate. That knowledge, in turn, may provide new avenues for pursuing treatment of neurological disorders or injury in humans."

Next, the researchers will examine what other genes, in addition to Sox10, play a role in the process by which neural-crest stem cells differentiate into microvillous neurons. They also plan to look at whether or not neural-crest cells give rise to new microvillous neurons during olfactory regeneration that happens after the embryonic stage of development.

###

Funding for the research outlined in the eLIFE paper, "Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish," was provided by the National Institutes of Health and the Gordon Ross Postdoctoral Fellowship. Brian N. Peng, a former undergraduate student (BS '12) at Caltech, also contributed to the study. A new open-access, high-impact journal, eLIFE is backed by three of the most prestigious biomedical research funders in the world: the Howard Hughes Medical Institute, the Max Planck Society, and the Wellcome Trust.

Written by Katie Neith


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/ciot-dos032513.php

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Monday, March 25, 2013

Suspect in Colorado killing had a 'bad, bad streak': governor

Colo. Dept. Of Corrections / AP

This undated photo released by the Colorado Department of Corrections shows paroled inmate Evan Spencer Ebel.

By Tom Brown, Reuters

Colorado Governor John Hickenlooper, a longtime family friend of a prime suspect in the shooting death of the state's prisons chief, said on Sunday that the now-dead suspect always seemed to suffer from a "streak of cruelty and anger."

Hickenlooper said he and Jack Ebel, the father of white supremacist ex-convict Evan Ebel, had been friends for more than 30 years and that he had spoken to him since the 28-year-old parolee from Denver emerged as a lead suspect in the shooting last Tuesday of Tom Clements, executive director of the Colorado Department of Corrections.

"From the beginning, his son just seemed to have this bad streak, a streak of cruelty and anger," Hickenlooper told CNN's "State of the Union."

"They did everything they could," he said. "They worked with Evan again and again but to no avail. He had a bad, bad streak."

Evan Ebel was killed by police on Thursday after a high-speed chase through Decatur, Texas. He is also a suspect in the killing of pizza delivery man Nathan Leon in Denver, police there have said.

Hickenlooper said an investigation is continuing and that "all the signs" in the Clements killing seemed to point to Ebel, whom he confirmed had been connected to a prison-based white supremacist group.

"We can't see clearly what a motive was," he added.

The governor, who said his own personal security had been beefed up recent days, did not rule out the possibility that the Clements killing had been ordered by jailed white supremacist gang leaders targeting public officials from behind bars.

Lieutenant Jeff Kramer, a spokesman for the sheriff's office in El Paso County, Colorado, said on Sunday that Evan Ebel was definitely considered a suspect in the death of Clements, 58, who was shot on Tuesday when he answered the door at his home about 45 miles south of Denver.

Shell casings found at Clements' home were the same brand and caliber of the Hornady 9-mm bullets Ebel fired at Texas police, according to the search warrant filed in Texas for police to search Ebel's Cadillac.

"We're still waiting for the results of some ballistics testing that we're doing up here in Colorado ... to see if the gun used in Texas is the same gun used in the Tom Clements homicide case," Kramer said.

Ebel was a member of a white supremacist prison gang, the 211 Crew, and had been paroled in the Denver area, a law enforcement official said.

Authorities have said they were looking for ties between the death of Clements and the January killing of Mark Hasse, a prosecutor in the Kaufman County District Attorney's Office. Kaufman County is east of Dallas.

Copyright 2013 Thomson Reuters. Click for restrictions.

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/29f07ef6/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A30C240C174430A70A0Esuspect0Ein0Ecolorado0Ekilling0Ehad0Ea0Ebad0Ebad0Estreak0Egovernor0Dlite/story01.htm

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Lindsay Lohan: Cleared in Fortune Teller Assault Case!

Source: http://www.thehollywoodgossip.com/2013/03/lindsay-lohan-cleared-in-fortune-teller-assault-case/

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Sunday, March 24, 2013

The Exciting Uncertainty At The Intersection Of Content And Commerce

crossingEditor's note:?Mike Jones is CEO of Science, Inc., a Los Angeles-based technology studio. Content and commerce have always had a symbiotic relationship that many traditional content providers tried to separate. The slow adoption of all that the digital revolution has to offer ? curation, aggregation, social, and automation ? has also hobbled many traditional content providers.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/0N3-nDQuvoc/

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